Lowe plays Lloyd Rockwell, a high-powered New York advertising executive.
Friel plays Susie Wilding, a junior ad rep for the same firm in London. At the behest of their bosses, they trade jobs temporarily.
And as Lloyd begins life in Susie's cramped, pet-ridden London home, and Susie takes over Lloyd's minimalist New York apartment, it becomes clear that the pair (who have never met) despise each other.
It is also just as obvious that they will fall in love, so once the main plot kicks in - in which someone tries to sabotage the experiment and our heroes band together to stop them - things become a little more interesting.
It's all terribly predictable, though, and instantly forgettable. Khandi Alexander (CSI: Miami) also stars.
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