More a fugue than a requiem, this is a harrowing portrait of four people with one-way tickets to tragedy. Coney Island widow Sara (Ellen Burstyn), an addled TV couch potato, rarely sees junkie son Jared Leto, except when he wants to pawn the TV. Told she's been selected to appear on a TV game show, Sara goes to a slimming clinic, soon becoming addicted to the pills they give her. While Sara is upping the dose and careering into hallucination and madness, Leto, girlfriend Jennifer Connelly and street friend Marlon Wayans, their honeymoon as drug dealers quickly over, are sliding down their own descending spirals of dependency. Images are repeated time and again (especially impressionistic drug-taking) and you may find the sheer intensity of the last half-hour altogether too much, provoking a shrug rather than a shudder before the end. Burstyn is amazing though, and Leto, Connelly and Wayans hardly less good.